However, while some randomized controlled trials of short-term interventions (2 weeks to 6 months) with supplementary nitrate have shown that dietary nitrate supplementation among patients with prediabetes or diabetes can significantly affect the level of serum glucose or insulin in the body, others have shown that nitrate supplementation has no significant effect on blood pressure, insulin sensitivity, and other metabolic parameters in patients. This evidence concerns the gene INS and prediabetes syndrome.