In the aforementioned report showing the relationship between lung squamous cell carcinoma prognosis and FSP1 and GPX4 expression, the combination of iFSP1 and RSL3-induced marked ferroptosis, and the same was true when FSP1 and GPX4 were knocked out by CRISPR–Cas9 [17]. This evidence concerns the gene AIFM2 and squamous cell lung carcinoma.