The GPX4-positive group had significantly higher invasion depth (p = 0.014), lymph node metastasis (p = 0.001), lymphatic involvement (p = 0.019), vascular involvement (p = 0.011), and disease stage (p = 0.002) than the GPX4-negative group (Table 1). Here, GPX4 is linked to metastatic malignant neoplasm in the lymph nodes.