Inversely, CACYBP could promote tumor progression by regulating apoptosis, cell proliferation and invasion and arresting the cell cycle in many cancers, such as hepatocellular carcinoma (HCC) (Lian et al. 2019), colon cancer (Zhai et al. 2017) and osteosarcoma (Zhao et al. 2020). This evidence concerns the gene CACYBP and osteosarcoma.