CD274 and neoplasm: Interestingly, however, the patient had a higher signature score for complement cascade and myeloid-derived suppressor cells (Fig. 1C), indicative of inflammation and immunosuppression in the CMS4 subtype.8 This patient had the highest tumor cell PD-L1 expression (20%) amongst the 32 patients, completed 100 weeks of treatment with bintrafusp alfa, and had a duration of response of 8.3 months.