In a group of 44 overweight/obese women with one or more characteristics of metabolic syndrome, following a diet based on the DGA 2010 for 8 weeks resulted in magnitudinal changes in SAA, MMP3, s-ICAM1, s-VCAM1, MDC, Eotaxin, LPS stimulated TNFα, CD3/CD28 treated IL-17β compared to the group following a ‘typical American diet’. The gene discussed is CCL22; the disease is metabolic syndrome.