TARDBP and amyotrophic lateral sclerosis: It is worthy noting that, in addition to RNPs, the delivery of other vital cargos which depends on anterograde transport to reach the pre-synaptic compartment (e.g., synaptic vesicles precursors, mitochondria and proteins [139, 140, 156, 157]) may also become compromised in TDP-43-ALS.