Obesity may lead to disturbed homeostasis between adipocytes and immune cells, and cause M1 macrophages fragmentation and polarization, activating the NLRP3 inflammatory to massively secrete IL-1β to exacerbate pro-inflammatory responses, a process that has been found to be involved in type 1 diabetes mellitus (T1DM) [74–76]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.