In general, T1DM is considered an immune disease [83], and the role of NLRP3 in T1DM remains to be investigated; whereas, recent studies point to a greater incidence of T1DM with obesity [73], possibly for that obesity leads to immunogenicity and glucose dysregulation, thereby contributing to insulin resistance in patients with T1DM. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.