CFLAR and endometrial cancer: For instance, a study showed that the dicoumarol derivative spindlactone A (SPL-A) sensitized endometrial cancer Ishikawa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through the downregulation of the expression of cellular FLICE-like inhibitory protein (c-FLIP), Bcl-2, Bcl-xl and Mcl-1 and the upregulation of p53 expression, cleaved poly-(adenosine diphosphate-ribose) polymerase (PARP) levels, and caspase activity [96].