TP53 and colorectal carcinoma: Our results show a combination of BMX and TMZ triggers cell cycle arrest, senescence, autophagy, and apoptosis in CRC cells via upregulation of p53/p21/E2F3/Bax, which in turn was compromised by the crosstalk of the downregulating Wnt/β-catenin/cyclin D1/c-Myc /p62 pathways.