For example, both interleukins mediate the recruitment of macrophages, T cells and natural killer (NK) cells supporting immune surveillance and elimination of senescent cancer cells [32] but also create a chronic inflammatory TME driving cancer development [73] and attract myeloid derived suppressor cells that suppress T [264] and NK cells [196] and blocks IL-1α signaling, preventing paracrine senescence in neighboring cancer cells [265]. Here, IL1A is linked to cancer.