Univariate logistic regression analysis of the development cohort showed that, the diabetes duration, history of hypertension, CKD, mean arterial pressure, WBC, PLT, 25(OH)D3, NT-proBNP, serum potassium, PBG, discharge Scr, and RRT rate were risk factors that affect the renal function of diabetic patients with AKI (p < 0.05). The gene discussed is NPPB; the disease is hypertensive disorder.