Notably, the effects of the downstream targets of these DE-miRNAs in the regulation of osteogenic differentiation were also demonstrated, including FOXP1, MAPK14 CSF1, etc. For instance, FOXP1 facilitates osteogenic differentiation of adipose-derived mesenchymal stem cells and bone regeneration in osteoporosis [41]. This evidence concerns the gene CSF1 and osteoporosis.