In consistent with those previous reports, our institution establishes and validates a prognostic nomogram including five risk factors (age, number of positive LN, tumor size, grade and Ki-67) accurately predict 5-year BC specific survival after mastectomy without adjuvant radiotherapy, which provides a practical stratification system to identify “high-risk” BC patients who might be indicated for adjuvant RT [15]. This evidence concerns the gene MKI67 and breast cancer.