In comparison with Sham group and shNtrk1 + Thy-1 GN group, the expression of pSTAT3/STAT3, pp38/p38 and pERK/ERK proteins in glomeruli of shNC + Thy-1 GN group significantly increased (P < 0.01) (Fig. 5H). The gene discussed is EIF2AK3; the disease is ganglioneuroma.