The disease also presents with an increase in gamma-glutamyl transferase (GGT) activity and a moderate increase in aminotransferases: aspartate (AST) and alanine (ALT) levels (Lindor et al. 2009) which do not have diagnostic significance, but could point to the overlap syndrome of autoimmune hepatitis (AIH) with PBC. Here, GPT is linked to primary biliary cholangitis.