Furthermore, TNFRSF12A (TWEAK-R), NT5E (CD73), and TGFB1/TGFBR1 were genes where low expression was significantly associated with increased survival in both cervical cancer and HNSCC, demonstrating that high expression of these immune genes is detrimental to outcome. The gene discussed is TNFRSF12A; the disease is head and neck squamous cell carcinoma.