To confirm that the loss of LRP1 inhibited tumor growth due to the inability of tumors to repress Tsp-1, we crossed the LysM-Cre-LRP1−/− with Tsp1−/− mice to generate double-knockout (DKO) mice that lacked Tsp-1 globally and LRP1 in myeloid cells (Supplementary Fig. S9B). The gene discussed is THBS1; the disease is neoplasm.