The Endo_EC gene cluster had nine genes, including Notch1 and Foxc2 (Fig. 6Bii), which expressed at all stages and were preferentially related to Hypoplastic Left Heart Syndrome (HLHS), Bicuspid Aortic Aalve (BAV), and Tetralogy of Fallot (TOF). This evidence concerns the gene FOXC2 and hypoplastic left heart syndrome.