The Endo_EC gene cluster had nine genes, including Notch1 and Foxc2 (Fig. 6Bii), which expressed at all stages and were preferentially related to Hypoplastic Left Heart Syndrome (HLHS), Bicuspid Aortic Aalve (BAV), and Tetralogy of Fallot (TOF). The gene discussed is NOTCH1; the disease is Tetralogy of Fallot.