Cimetidine, a potential SLC47A1 inhibitor53, also increased IKE-induced tumor suppression in xenograft mouse models involving the implantation of MIA PaCa2, HT-1080 (a human fibrosarcoma cell line), or A549 (human lung carcinoma cell line) cells (Fig. 7g–i). This evidence concerns the gene SLC47A1 and fibrosarcoma.