Consistent with the siRNA screen, the knockdown of SLC47A1 using small hairpin RNA (shRNA) also sensitized RSL3 and/or erastin to growth inhibition in PDAC (Fig. 2a, b), lung tumor cells (A549), breast tumor cells (MCF-7) and ovarian tumor cells (SKOV-3) (Supplementary Fig. 2a). This evidence concerns the gene SLC47A1 and breast neoplasm.