MCM8 and neoplasm: For RFS, vascular invasion (HR (95%CI) 2.227(1.282-3.869), P = 0.005), without tumor encapsulation (HR (95%CI) 0.246(0.145-0.415), P <0.001) and higher MCM8 protein level (HR (95%CI) 1.657(1.002-2.741), P = 0.049) were independent risk factors (Table 3).