MCM8 and hepatocellular carcinoma: We investigated the genetic alteration of MCM8 in a cohort of 372 HCC patients in the cBioPortal database and found 224 (60%) of the queried patients have detected alteration of MCM8, including 1case of missense mutation, 1 case of amplification, 214 cases of high expression and 8 cases of low expression (Figure 5A).