MCM8 and hepatocellular carcinoma: In addition, ROC analysis demonstrated that MCM8 mRNA levels exhibited an excellent capacity to discriminate the HCC and normal liver tissues, with area under the curve (AUC) for TCGA, GSE76427 and GSE54236 being 0.854, 0.807 and 0.798, respectively (all P<0.001, Figure 2D).