Our luciferase reporter assay identified the SALL4 failed to interaction of the promotor of PTEN, and combined with previous studies showed that SALL4 could modulate the miR-188-5p, which suppressed PTEN messenger RNA and protein expression in gastric cancer [23], and moreover SALL4 associates with nucleosome remodeling deacetylase (NuRD) to silence tumor-suppressor genes, such as PTEN [24], thereby SALL4 may affect the expression and activation of PTEN indirectly. The gene discussed is PTEN; the disease is gastric cancer.