The above findings were consistent with the results of western blotting that the protein expressions of MMP2 and MMP9, which are enzymes are able to degrade various components of extracellular matrix (ECM) proteins and promote cancer cell growth and migration, in HepG2 and SMMC-7721 cells were significantly higher in SALL4 mimic group than those in SALL4 mimic NC group. This evidence concerns the gene MMP2 and cancer.