Moreover, after the up-regulation of SALL4, the protein expressions of MMP2 and MMP9 in HepG2 and SMMC-7721 cells greatly rose, which also further suggested that SALL4 can enhance the migration and invasion of HepG2 and SMMC-7721 cells, and moreover, SALL4 mimic also increased the HCC tumor progression in nude mice experiment, identified the tumorigenicity of SALL4 in hepatic cancer. This evidence concerns the gene MMP2 and neoplasm.