Moreover, we have also successfully utilized WTC-based drug testing assays earlier to study the tumor-suppressive effects of anticancer compound RITA (Reactivation of p53 and Induction of Tumor cell Apoptosis), aminoflavone (AF), and oncrasin-1 (ONC-1), in combination with poly(ADP-ribose) polymerase (PARP) inhibitors or 4-hydroxy-tamoxifen (60, 61). Here, TP53 is linked to neoplasm.