Infection of ITGB1 KO, B2M KO, and B2M/ITGB1 double KO (DKO) cell clones in the HAP1 cells at low m.o.i. with a GFP-expressing VV revealed a significant reduction associated with B2M inactivation, and a smaller effect associated to ITGB1 inactivation, as measured by both viral production and GFP expression (Fig 5D and 5E). This evidence concerns the gene B2M and infection.