Since pDNA‐PKcs expression positively correlates with tumor progression (Lan et al, 2016), and in the light of our meta‐analysis, it is tempting to hypothesize that in tumors where the cGAS‐STING pathway fuels tumorigenesis, the use of DNA‐PKcs inhibitor may facilitate tumor clearance. The gene discussed is STING1; the disease is neoplasm.