-Age ≥40 years-Symptomatic HF- EF ≥45%-Elevated plasma NT-proBNP levels-Diuretic therapy-SBP <140 mmHg or 160 mmHg if on ≥3 antihypertensive drugs-eGFR ≥30 ml/min/1.73 m2-Potassium concentration ≤5.2 mmol/l. This evidence concerns the gene NPPB and hydrops fetalis.