Recent data showed a prognostic impact of Sodium-glucose Cotransporter-2 (SGLT2) inhibitors in HFpEF patients, thus starting to modify the pharmacological approach to HFpEF.5,6 As regards ARNI, the PARAGON trial failed for just a few events to demonstrate a prognostic impact of sacubitril/valsartan in HFpEF patients compared with valsartan; moreover, from a combined analysis of PARADIGM-HF and PARAGON-HF trials,7 the efficacy of sacubitril/valsartan was evident up to an EF value of 55%, thus including a subgroup of HFpEF patients, with a beneficial effect in women also seen at higher EFs. Here, SLC5A2 is linked to hydrops fetalis.