TMPRSS5 and Charcot-Marie-Tooth disease: Patients with Charcot-Marie-Tooth disease had significantly increased NFL (SMD, 1.11 [95% CI, 0.86 to 1.36]; P < .001; I2 = 0%) and transmembrane protease serine 5 (SMD, 1.68 [95% CI, 1.43 to 1.93]; P = .001; I2 = 0%) compared with controls.