IDH1 and cancer: One notable example was reported in 2009 byDang et al., who showed that a mutant isocitrate dehydrogenase variant(IDH1 R132H)—already known to be associated with numerous cancers—possessedthe ability to perform a new NADP(H)-dependent reaction, the reductionof 2OG to 2-hydroxyglutarate (2HG).