For example, high concentration of proinflammatory cytokines TNF‐alpha and IL‐6 were found in patients with major depression (Beurel et al., 2020; Dowlati et al., 2010) and clinical trials have indicated beneficial effects of anti‐inflammatory medications on major depression symptoms (Akhondzadeh et al., 2009; Muller et al., 2006). This evidence concerns the gene TNF and major depressive disorder.