A possible explanation for these observations is that mature neurons produce and retain NKCC1 mRNA under normal conditions and that significant protein translation in the somato-dendritic compartment, as evidenced by a large number of studies on depolarizing GABA actions, would only start under pathophysiological conditions, such as seizures or stroke (Kaila, Price, et al. This evidence concerns the gene SLC12A2 and stroke disorder.