The specific deletion of Tnfaip3 only in epithelial cells (Tnfaip3ΔIEC) does not have a pathological phenotype but sensitize these mice to DSS‐induced colitis and TNF‐induced apoptosis: 24 h after injection of a sublethal TNF dose, LYZ‐containing PCs and expression of PC‐specific AMPs were reduced (Vereecke et al, 2014). The gene discussed is TNFAIP3; the disease is colitis.