Also, intestinal and myeloid deletion of A20 (TNFAIP3, encoded by Tnfaip3 in mice, Tnfaip3ΔIEC/Δmyel), an inhibitor of NF‐κB and apoptosis, induces ileitis and severe colitis characterized by IEC apoptosis, goblet cell, and PC loss. Here, TNFAIP3 is linked to colitis.