To date, some studies have investigated the genetic profile of the ductal adenocarcinoma genotype, which has conserved upregulation of several pathways, including DNA damage repair (DDR), Wnt‐β‐catenin, and phosphoinositide 3‐kinase (PI3K) pathways, that drive the aggressive characteristics.6, 7, 8, 9. The gene discussed is PIK3CA; the disease is invasive ductal breast carcinoma.