Although the reported incidence of PTEN alterations in East Asian patients with prostate cancer ranges from 10%–34%, which is lower than that in the United States and Western Europe (18%–40%),24, 25, 26 the results of this study suggest that East Asians patients with ductal adenocarcinoma may have PTEN alterations at a similar frequency. The gene discussed is PTEN; the disease is Familial prostate cancer.