Myc-up tumors showed high levels of stem cell polycomb signature and CpG hypermethylation, while immune-up tumors showed a T-cell helper 1 (Th1) oriented tumor microenvironment harboring high levels of PDA expression and proinflammatory mediators (tumor necrosis factor [TNF], IRF family, interleukin [IL]-12). Here, TNF is linked to Patent ductus arteriosus.