APP and Alzheimer disease: Mice treated with LPS and genetic AD-model (APP/PS1 transgenic)mice demonstrated much stronger fluorescence responses over untreatedand WT mice indicating the association between increased viscosityand H2O2 to AD pathology (Figure 5C).101 Fluorophoresthat monitor protein aggregates such as amyloid β (Aβ)have also been developed as Aβ and oxidative stress are bothhallmarks of AD pathology.