HLA-DRB5 and dementia: This may have led to lower power or spurious findings, especially for HLA-DRB5 where only 12 sites were included in the current study, compared to 48 sites in the study by Yu et al. [2] Using dementia information from registers provides the possibility to follow individuals after end of study, but it should be noted that register-based diagnoses have excellent specificity, but rather low sensitivity [11].