Suetens et al. reported in two sequential articles that tumor motility-related genes such as CCDC88A, ROCK1, NEXN, FN1, MYH10 and MYH9 were downregulated after 2 Gy carbon ion irradiation; among them, CCDC88A, ROCK1, FN1, and MYH9 were also down-regulated after 0.5 Gy carbon ion irradiation [27, 28]. Here, NEXN is linked to neoplasm.