Among the genes associated with differentially methylated regions are CATSPERG, which is associated to an estrogenic hypomethylated Alu sequence, more likely to be present in the CMA3+ sperm fraction of infertile patients, and CATSPERZ, which is associated to an estrogenic hypomethylated Alu sequence more likely to be present in the CMA3− sperm fraction of infertile patients. The gene discussed is CATSPERZ; the disease is Infertility.