The multivariable analysis revealed that exercising, atherosclerotic cardiovascular disease history, hypertension history, and total cholesterol were protective factors in the control of glycosylated hemoglobin (HbA1c), while the family history, insulin dose, central adiposity, complications, T2DM duration, hypertension, and blood pressure were the risk factors for the increased HbA1c. The gene discussed is INS; the disease is Hypertension.