MUC1 positive (Capan-2, CFPAC-1, PANC-1), MUC1 negative (SW1990) pancreatic cancer lines and Normal pancreatic duct cell line hTERT-HPNE were treated with different concentrations of human IgG-MMAE, HzMUC1-MMAE and analyzed using colony formation assay. This evidence concerns the gene MUC1 and familial pancreatic carcinoma.