APOE and Alzheimer disease: Although we observed that CSF ApoJ and ApoA-I are closely correlated (Fig. 3), CSF ApoA-I and ApoJ were not significantly correlated with each other when we adjust for age, sex, and race (Supplemental Figure 4) CSF ApoA-I and ApoJ/Clusterin were both significantly lower in MCI than CN but not in AD, whereas CSF ApoE was significantly lower in AD subjects than in CN controls but not in MCI (Fig. 4 and Table 2).