Recently, a large-scale study using a two-sample MR approach investigated the causal effects of eight major serum lipid biomarkers toward different AMD subtypes [6].Using a multivariable MR method based on Bayesian model averaging applied to exposure factors, the study identified lipid metabolism (apolipoprotein A1 and apolipoprotein B) functions in drusen formation, in particular at early and intermediate AMD development stages. The gene discussed is APOB; the disease is age-related macular degeneration.