MTAP and glioblastoma: Interestingly and contrary to other authors, Menezes et al. have shown that reduced MTAP expression, which is a result of higher MTAP loss frequency in GBM, is associated with better prognosis in adult glioblastoma; although MTAP loss does not affect cell line proliferation, invasion, and migration as shown in their study results based on in vitro models [7].