The serine protease TPP1 regulates lysosomal proteins [62], as well as mitochondrial trafficking and cellular metabolism [63], suggesting a role in cellular metabolism [64].The chemokine CCL20 regulates innate immunity and inflammation in skin and mucosa [65], is upregulated by LDL in smooth muscle of vascular structures, and is a reported biomarker for aortic aneurysms [66, 67]. Here, TPP1 is linked to aortic aneurysm.