As an acute marker of early acute kidney injury, KIM1 is predictive of long-term renal outcome [97] and is reported to have protective functions in renal ischemia–reperfusion injury, promote renal graft recovery, have a role in renal cancer pathophysiology and serve as a biomarker for sepsis-induced acute kidney injury [98–102]. The gene discussed is HAVCR1; the disease is kidney injury.