AQP1 and kidney disorder: Among them, 40 proteins were up-regulated, and 31 were down-regulated, as demonstrated in Fig. 1A. Among the DEPs there were several proteins have been reported in the prediction of nephropathies, such as Immunoglobulin heavy variable 1–18 (IGHV1-18) [23], Beta-2-microglobulin (B2M) [24], Leucine-rich alpha-2-glycoprotein (LRG [25], and Aquaporin-1(APQ1) [26].