Overexpression of Notch1 and Notch4 are prognostic markers in patients with HCC after curative resection, indicating shorter disease-free survival (Notch1, P = 0.029) and shorter disease-specific survival (Notch1 and Notch4, P = 0.039 and 0.012, respectively) [42]. The gene discussed is NOTCH4; the disease is hepatocellular carcinoma.