NFIC KD with sh494 led to significant increases in apoptosis in cell lines THP-1 (ninefold), HL60 (eightfold), NB4 (eightfold) and TF-1(tenfold) (Fig. 5b) and a similar effect was observed in AML patient samples ranging from 1.6 to 4-fold (Fig. 5c). The gene discussed is NFIC; the disease is acute myeloid leukemia.