For example, downregulation of HLA-DR and CD86 and upregulation of TIM-3 and HLA-ABC compared to healthy monocytes were only significant in moderate but not in mild COVID-19 monocytes, and the increased expression of CD80 in mild COVID-19 compared to healthy monocytes was not apparent in moderate COVID-19 (Fig. 1b). This evidence concerns the gene CD86 and COVID-19.