The majority of the top 40 genes significantly downregulated in COVID-19 monocytes from these downregulated pathways consisted of different interferons (IFNA1, IFNA2, IFNA14, and IFNB1), interferon-stimulated genes (IFIT3, ISG15, IFIT2, ISG20, IRF7, and MX2) and pathogen-sensing receptors (TLR7, AIM2, Fig. 5f). The gene discussed is ISG15; the disease is COVID-19.