Heatmap showing the top 40 upregulated genes from the enriched pathways demonstrated a somewhat variable expression patterns among COVID-19 monocytes and included a number of type I interferon-stimulated genes (IFI27, IFITM2, IFI6, IFITM3, MX1), metabolic enzymes (ASAH1, CYP27A1, SGPP2, SPHK1) and others (Fig. 2d). Here, CYP27A1 is linked to COVID-19.