IFIH1 and COVID-19: Interestingly, downregulated pathways in stimulated COVID-19 monocytes compared to stimulated healthy donor monocytes included most of the canonical immunological functions expected for innate immune cells upon virus sensing, i.e., interferon signaling, RIG-I/MDA5-mediated induction of interferons, activation of TCR signaling in T cells, innate immune functions and interactions with non-lymphoid cells (Fig. 5e and Dataset 8).