LAMTOR5 and Bloom syndrome: Among them, we noticed that the DEG number in xip after BLM treatment (xip-BLM/xip-Mock) was obviously smaller (338 up- and 144 downregulated genes) when compared to those in WT after BLM treatment (WT-BLM/WT-Mock, 771 up- and 742 downregulated genes), suggesting that the transcriptional response to BLM challenge may be less severe in xip mutant when compared with that in WT (Supplementary Fig. 9), which was in line with our quantitative RT-qPCR examination (Fig. 3b and Supplementary Fig. 10), and was further supported by the principal component analysis (PCA) (Supplementary Fig. 11).