STAT3 and central nervous system cancer: Others have reported that genetic abrogation of constitutive STAT3 signaling, a downstream molecule of IFN signaling, leads to increased release of inflammatory cytokines by human glioblastoma cells which in turn increased dendritic cell maturation [32], Moreover, pharmacological inhibition of constitutive STAT3 signaling decreased proliferation of U251 human glioblastoma cells in vitro and increased overall survival in the mouse glioma model Tu-9648 in vivo [33,34].