Electroacupuncture at Dachangshu (BL25) has been found to significantly downregulate P2Y12 expression in the PFC, attenuating microglial activation and thereby inhibiting IL-1β expression in the PFC, leading to reductions in both visceral pain and depressive symptoms in mice with IBD (Li et al., 2021). This evidence concerns the gene P2RY12 and irritable bowel syndrome.