Electroacupuncture at Dachangshu (BL25) has been found to significantly downregulate P2Y12 expression in the PFC, attenuating microglial activation and thereby inhibiting IL-1β expression in the PFC, leading to reductions in both visceral pain and depressive symptoms in mice with IBD (Li et al., 2021). The gene discussed is P2RY12; the disease is inflammatory bowel disease.