AQP4 and ischemia: The presence of AQP4 exacerbates post-ischemic cytotoxic edema in an IS model, and several studies have demonstrated that AQP4 knockout or AQP4 gene silence attenuates ischemia-induced cellular edema, reduces mortality, restores motor function, and improves long-term outcomes (Hirt et al., 2017; Pirici et al., 2017).